Creating a multi-Region architecture with Amazon Route 53 and Amazon CloudFront will address their requirements effectively. Amazon Route 53 can help route the users to the nearest deployment to reduce latency and improve disaster recovery by rerouting traffic in case of a region failure, while Amazon CloudFront can cache the content close to the users around the world. This ensures lower latency for a globally dispersed user base. Utilizing multiple Regions alone does not address latency to the same extent, as there is no mention of a content delivery network (CDN). Creating additional Availability Zones within a single Region will improve high availability but does not consider global latency or disaster recovery across regions or countries. AWS Direct Connect increases the data transfer rate between on-premises systems and AWS but doesn't directly address global latency for end-users.