Amazon CloudFront is a content delivery network (CDN) service that securely delivers data, videos, applications, and APIs to customers globally with low latency and high transfer speeds. By using a global network of edge locations, CloudFront caches copies of your static content close to users, thereby reducing latency and improving users' content load times. This makes it the best choice in scenarios where a company is expanding globally and requires an optimized content delivery solution. Other options like Direct Connect and VPN are more suitable for dedicated connections between on-premise networks and AWS or encrypted connections across the Internet, respectively, rather than for optimizing content delivery to end users. Multi-tier network architecture is a broad concept and does not directly decrease latency or increase load times for global content delivery.