Configuring TLS ensures that data transmitted between the web application and its clients is encrypted, which protects the confidentiality and integrity of the data. TLS provides a secure channel over an insecure network, like the internet, by encrypting the data during transmission. The use of TLS also helps in preventing eavesdropping and tampering. Enabling full disk encryption, while useful for protecting data at rest, does not secure data in transit. Implementing tokenization primarily secures sensitive data by replacing it with unique identification symbols that retain all the essential information without compromising its security, but it's not a means to encrypt data during transmission. Data masking protects sensitive information by obfuscating it, but again, does not secure data in transit.