To disable System Restore, one should navigate to the 'System Protection' tab in the 'System Properties' dialog box, select the drive, and click 'Configure'. Then, select 'Disable system protection' and apply the changes. This procedure ensures that no new restore points are created, which is useful when attempting to cleanse a system of malware by preventing the malware from being saved in a restore point. 'Unchecking the drive in Disk Management', 'Deleting all restore points from the Control Panel', and 'Formatting the hard drive' do not correctly represent the method to disable System Restore and have much broader effects or do not achieve the goal.