Enabling cross-Region replication may lead to additional costs due to the replication process itself, and might not necessarily reduce data transfer costs. It depends on the specific architecture, use case, and where the access requests are coming from. If the majority of requests are localized, it is better to place and replicate data within the Region of the users to minimize latency and costs. However, indiscriminate replication across regions without a thorough cost-benefit analysis could increase rather than decrease costs.