The correct answer is 'True' because instances that are optimized for I/O-intensive workloads, such as the I3 or R5 families, offer high IOPS (input/output operations per second) and throughput, which are crucial for high levels of sustained random I/O access. These instances provide NVMe SSD-backed instance storage optimized for high random I/O performance and high sequential read/write throughput, making them ideal for applications that require these characteristics. Other instance families without I/O optimization would not provide the same level of performance for such workloads and could result in suboptimal application performance.