Secure File Transfer Protocol (SFTP) utilizes SSH (Secure Shell) for secure file transfer, which typically operates over port 22. It is important to know both the protocol and the corresponding port number for networking tasks and security. FTP (File Transfer Protocol) over port 21 is not encrypted by default, making it less secure for transferring files. While SMTP (Simple Mail Transfer Protocol) does use port 25, it's used for sending emails, not for file transfers. Port 443 is commonly associated with HTTPS (Hypertext Transfer Protocol Secure), not SFTP. Remembering the specific port numbers associated with their protocols will help ensure secure network configuration and understanding.