To generate an EUI-64-based interface identifier, the MAC address is split in half and the hex value 0xFFFE is inserted into the middle. Furthermore, the universal/local bit (the seventh bit in the first byte of the MAC address) needs to be complemented. The given MAC address 00-1A-2B-3C-4D-5E, when converted to EUI-64, becomes 021A:2BFF:FE3C:4D5E, where '02' comes from '00' with the second least significant bit flipped to '1' (from 00000000 to 00000010 in binary). The other options provided are incorrect because they do not follow the process of generating an EUI-64-based interface identifier from a MAC address.