Which class of immunoglobulins is quantitatively measured in a radioallergosorbent test (RAST) to determine a patient's sensitization to specific allergens?
IgE
IgG
IgA
IgM
RAST is an in-vitro radioimmunoassay that detects and quantifies allergen-specific IgE bound to solid-phase allergen extracts. Elevated specific IgE levels indicate that the patient has been sensitized to the tested substance. Other immunoglobulin classes (IgG, IgM, IgA) are not measured by this assay and therefore do not provide information about Type I hypersensitivity reactions.
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