A medical assistant is reviewing the laboratory results for a patient with a diagnosis of primary hyperthyroidism. Which of the following levels of Thyroid-Stimulating Hormone (TSH) is the expected finding for this condition?
Decreased
Within normal limits
Highly variable without a pattern
Increased
In primary hyperthyroidism, the thyroid gland is overactive and produces an excess of thyroid hormones (T3 and T4). These high levels of circulating thyroid hormones signal the pituitary gland, via a negative feedback mechanism, to reduce its production of Thyroid-Stimulating Hormone (TSH). Consequently, the expected laboratory finding for primary hyperthyroidism is a decreased TSH level. An increased TSH level is characteristic of primary hypothyroidism, where the pituitary gland attempts to stimulate an underactive thyroid.
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