Choosing an AWS Region closer to your end-users can significantly reduce latency. An AWS Region operates independently of other Regions and consists of multiple, isolated locations known as Availability Zones, which ensures that resources are geographically closer to end-users. In contrast, AWS Wavelength is designed for applications that require ultra-low latency accessible by edge devices on a 5G network, and Amazon AppStream is a fully managed application streaming service but does not inherently reduce latency for end-users based on geography alone.