When initiating invasive ventilation in a patient with acute respiratory distress syndrome (ARDS), which ventilator setting is most important to reduce the risk of ventilator-induced lung injury?
Tidal volume of 6 mL/kg of predicted body weight
FiO2 set to 100%
Respiratory rate of 18 breaths per minute
Positive end-expiratory pressure (PEEP) of 5 cmH2O
Setting the tidal volume is crucial when initiating invasive ventilation in ARDS patients because using too high a tidal volume can cause ventilator-induced lung injury (VILI). Keeping the tidal volume at 6 mL/kg of predicted body weight helps to minimize this risk. While positive end-expiratory pressure (PEEP), respiratory rate, and FiO2 are also important settings, they do not directly correlate with lung injury prevention as effectively as tidal volume management.
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