Which obstetrical complication is characterized by the triad of hemolysis, elevated liver enzymes, and low platelet count (thrombocytopenia) and is considered a severe variant of pre-eclampsia?
Disseminated intravascular coagulation (DIC) of pregnancy
HELLP syndrome (Hemolysis, Elevated Liver enzymes, Low Platelet count) is a life-threatening obstetric emergency that may develop ante-partum or post-partum. It represents a severe form of pre-eclampsia and is defined by laboratory evidence of red-cell destruction, markedly elevated AST/ALT, and platelet counts typically below 100 000 /µL. Acute fatty liver of pregnancy can also raise liver enzymes but lacks the classic hemolysis and marked thrombocytopenia. Disseminated intravascular coagulation produces thrombocytopenia and hemolysis yet is a secondary coagulopathy rather than a hypertensive variant. Gestational diabetes mellitus involves carbohydrate intolerance and does not present with this hematologic-hepatic triad.
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BCEN CEN
Gastrointestinal, Genitourinary, Gynecology, and Obstetrical
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