An adult patient presents to the emergency department with sharp, pleuritic chest pain that improves when leaning forward. The initial 12-lead ECG shows diffuse concave ST-segment elevations in leads I, II, aVL, aVF, and V3-V6. Which additional ECG finding, when present across multiple leads, most strongly supports the diagnosis of acute pericarditis rather than ST-elevation myocardial infarction or early repolarization?
Development of pathologic Q waves in the leads with ST elevation
Reciprocal ST-segment depression in leads II, III, and aVF
PR-segment depression in multiple limb and precordial leads
New onset bundle-branch block accompanying the ST elevation
Acute pericarditis classically produces a stage I ECG pattern of widespread, concave ("saddle-shaped") ST-segment elevation accompanied by PR-segment depression in most leads, with reciprocal PR elevation in aVR. PR-segment depression reflects atrial subepicardial injury and, together with diffuse ST elevation that does not localize to a single coronary territory, distinguishes pericarditis from STEMI or benign early repolarization. The other options represent typical findings of myocardial infarction (reciprocal ST depression, pathologic Q waves), hyperkalemia (tall peaked T waves with wide QRS), or conduction disease (new bundle-branch block), none of which are characteristic of uncomplicated acute pericarditis.
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