Hepatocellular inflammation in acute viral hepatitis damages the liver's ability to conjugate bilirubin and secrete it into bile canaliculi. Accumulation of both conjugated and unconjugated bilirubin in the bloodstream increases serum levels above about 3 mg/dL, producing the yellow discoloration of the skin and sclera. While hemolysis, extrahepatic biliary obstruction, and pigment-deposition disorders can also cause yellow skin, they are not the primary cause of jaundice in acute hepatitis.
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BCEN CEN
Gastrointestinal, Genitourinary, Gynecology, and Obstetrical
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