A patient presents to the emergency department with a sudden onset of severe epigastric pain that radiates to the back, accompanied by nausea and vomiting. Which of the following laboratory findings would be most indicative of acute pancreatitis?
Hyperglycemia and hypocalcemia
Serum lipase and amylase levels greater than three times the upper limit of normal
Elevated aspartate aminotransferase (AST) and alanine aminotransferase (ALT)
Elevated white blood cell (WBC) count and C-reactive protein (CRP)
The diagnosis of acute pancreatitis requires meeting at least two of three criteria: characteristic abdominal pain, serum amylase or lipase levels at least three times the upper limit of normal, and characteristic imaging findings. Therefore, significantly elevated serum lipase and amylase are the most direct and indicative laboratory findings for acute pancreatitis. While leukocytosis (elevated WBC) and an elevated C-reactive protein are common due to inflammation, they are nonspecific. Elevated liver enzymes (AST/ALT) may suggest a biliary cause but are not primary diagnostic markers for pancreatitis itself. Hyperglycemia and hypocalcemia can be complications of pancreatitis but are not primary diagnostic indicators.
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BCEN CEN
Gastrointestinal, Genitourinary, Gynecology, and Obstetrical
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