A 45-year-old male who underwent lower-extremity orthopedic surgery 10 days ago presents to the emergency department with a swollen, painful right calf. Vital signs are: temperature 98.2 °F (36.8 °C), heart rate 84/min, blood pressure 128/78 mm Hg, respiratory rate 16/min, and SpO₂ 98 % on room air. He denies chest pain or shortness of breath. Based on this presentation, what is the most appropriate next step in management?
Order duplex (compression) ultrasonography of the affected leg.
Begin therapeutic anticoagulation to prevent clot propagation.
Elevate the extremity and apply a warm compress.
Obtain a D-dimer assay to rule out deep vein thrombosis.
His recent surgery and unilateral calf swelling give him a likely pretest probability of lower-extremity DVT under the Wells criteria. Guidelines from the American Society of Hematology and American College of Physicians recommend compression (duplex) ultrasonography as the first-line diagnostic study for patients with an intermediate-to-high pretest probability. A D-dimer is useful only to rule out DVT in low-risk patients, and empiric anticoagulation is generally reserved for situations where diagnostic imaging will be significantly delayed. Elevation and warm compresses provide comfort but neither confirm nor treat DVT.
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