A 34-year-old patient presents to the emergency department with acute dyspnea, expiratory wheezing, and use of accessory muscles. The patient has a history of asthma. Which medication is the most appropriate first-line intervention to provide rapid relief?
For a patient experiencing an acute asthma exacerbation, the priority is to rapidly reverse bronchoconstriction. Short-acting beta-agonists (SABAs) like albuterol are the first-line treatment as they are potent bronchodilators that relax airway smooth muscle, providing quick symptom relief. While systemic corticosteroids (like methylprednisolone) are crucial for managing the underlying inflammation and are given early, their onset of action is slower, making them a secondary priority to the immediate administration of a SABA. Ipratropium is an anticholinergic bronchodilator often used as an adjunctive therapy with a SABA in moderate to severe exacerbations, but it is not the primary single agent. IV magnesium sulfate is typically reserved for severe, refractory exacerbations that do not respond to initial SABA and corticosteroid therapy.
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