The utilization of prepared statements with parameterized queries is a robust defense against injection attacks as it separates the logic of the query from the data supplied by the user. In contrast to merely escaping user inputs, parameterized queries ensure that the provided data cannot interfere with the query structure, thereby mitigating the risk of these attacks. Periodic updates of the database management system and implementing input length restrictions may contribute to the overall security posture but will not directly prevent an attack where untrusted inputs are used to modify command execution. Escaping inputs manually without utilizing parameterized queries is less effective and more error-prone, leaving potential vulnerabilities.